The research studies the nature of the American-French relations during 1958-1969; the period during which Charles De Gaulle assumed the power in France.Charles De Gaulle, since he took power, pursued an independence policy apart from the outside world that aimed at bringing France back to the ranks of the great powers as it was in the past. That policy intersected with the USA as it was the leader of the West. The withdrawal of France from the NATO and developing its nuclear program were the considerable features of that rupture and intensive tension within the French-American relations.